ProhormonesSARMS

Ostarine (MK-2866) The Strongest Legal SARM – Build Lean Muscle

Ostarine (MK-2866 or Enobosarm) is a SARM (Selective Androgen Receptor Modulator) that was developed for the prevention and treatment of muscle wasting. Its full chemical name is (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide. It is currently undergoing clinical trials and may eventually be the medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testoserone Replacement Therapy.

Ostarine belongs to a class of chemicals known as SARMs or selective androgen receptor modulators. SARMS contain androgens. Androgens are a special kind of hormones that act as ligands (a molecule linked to another molecule) that connect to cellular androgen receptors (AR). The AR is integrated in a composite signal transduction conduit that ultimately leads to bigger expression of particular genes. This connection to the AR is what makes all prohormones and steroids give their muscle growth properties.

Selective receptor modulator is a drug that can both obstruct or fuel similar nuclear hormone receptor in different conditions. If it can obstruct or fuel a receptor in a tissue selective mode, it has the ability to replicate the important effects in one tissue and concurrently reduce the adverse effects of the natural or synthetic steroidal hormones in other tissues. Compared to testosterone and other anabolic steroids and pro hormones, the advantage of SARMs such as Ostarine (MK-2688) is that they do not have androgenic activity in non-skeletal-muscle tissues. Ostarine is effective in not only maintaining lean body mass (LBM) but actually increasing it.

How does Ostarine work?

Selective androgen receptor modulators (SARMs) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity. Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis, hence builds muscle.

So in essence, SARMs such as Ostarine causes muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids and prohormones, SARMs (as nonsteroidal agents) don’t produce the growth effect on prostate and other secondary sexual organs.

Ostarine in particular exerts its anabolic effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions from muscle wasting diseases (from age-related to AIDS or cancer-related), but is also has immense potential for muscle building for Bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations.

Dosages And Uses of Ostarine

Ostarine for bulking

As Ostarine is the most anabolic of the available SARMs, its first and formost use must be when trying to gain lean muscle. Now the gains in absolute weight won’t be comparable to steroids such as diannabol, however what will be gained will almost exclusivley be lean mass. Due to the lack of shutdown in comparison to steroids/prohormones, a PCT period is not needed and almost all the mass that is gained on Ostarine is kept once the cycle is finished.

Doses of 25mg for 4-6 weeks are the most common protocol for such goals. Over this 4-6 week period will typically produce 6lbs or 3kg of lean, keepable gains. However the abundant side effects of steroids/prohormones will not be present.

Users have as high as 36mg (only recommended for those who weigh in at 210lbs) for periods as long as 8 weeks. However the potential for suppression from such doses is higher and users would have to look into a PCT protocol after undergoing such a cycle.

Ostarine for cutting

Ostarine would primarily fit into a cutting protocol for the maintainance of muscle mass whilst reducing calories. One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic enviroment for loss of muscle tissue. As Ostarine has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss. Ostarine has also shown noticeable nutrient partioining effects among users, another reason why it can be of great help when cutting.

A 12.5-15mg dosing protocol for 4-6 weeks is good for cutting with Ostarine without undergoing any side effects or suppression. However it must be stated that due to the lack of androgenicity, muscle hardness and overall results are not as prominenant as with the SARM S-4.

Ostarine for Recomping

Recomping is where Ostarine really shines. The recomping effect of losing fat and gaining muscle at the same time is what the majority of users are looking for. Trying to achieve this when you are not absolutely new to training is extremely difficult. Where Ostarine shines for recomping is in its nutrient partioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. In fact many users report that Ostarine consumed at maintainace calories produces weight loss, whilst still getting increases in strength and muscle mass!

One of the most important factors of recomping is TIME. As you are trying to achieve multiple objectives, it requires a longer time period to notice good recomp effects so even when running steroids, these would have to be longer run injectible compounds as oppose to the short used liver toxic oral steroids/prohormones.

Although Ostarine is taken orally, as it is not methylated it is not as liver toxic as other oral steroids/prohormones. Therefore it can be run for longer than the standard 4 week period with the aforementioned compounds.

The dosing protocol of 12.5-25mg for 4-8 weeks will give excellent recomp effects. Diet must also be optimized to where calories are just above maintaninance with at least 30% coming from lean sources of protein to get the best recomp effect.

Ostarine for Injury Prevention

The effects of MK-2688 translate to anabolism in bone as well as skeletal muscle tissue, which means it could be used in the future for a wide variety of uses such as osteoporosis and as a concurrent treatment with drugs that reduce bone density. Therefore it has great application as a compound to use for rehabilitation of injuries, in particular bone and tendon related injuries.

Doses of 12.5mg per day is recommend for such purposes and improvement in joint movement that can be seen after just 6-8 days.

Timing of Doses

As Ostarine has a half life of around 24 hours, each of these doeses only has to be taken orally once a day, therefore its also offers an extremely convientinet supplementation intake.

Side Effects of Ostarine

The side effects of Ostarine are limited as it appears to be a relatively side effect friendly drug. Many of the adverse effects associated with anabolic steroids will not exist with this SARM; however, some will, although mildly.

Estrogenic side effects

The side effects of Ostarine should not include those of an estrogenic nature as the SARM does not aromatize. There is no conversion of testosterone to estrogen associated with this drug. Water retention, bloating, gynecomastia or high blood pressure due to water retention cannot occur. However, data shows that some increases in existing estrogen may occur, but should be very mild and not enough to warrant the use of an anti-estrogen. If this very slight increase is concerning, if an anti-estrogen is used, you may easily bottom out your estrogen levels, which can lead to numerous hormone imbalances and related effects.

Androgenic side effects

Androgenic side effects of Ostarine, despite directly affecting the androgen receptor should not exist. This compound does not convert to DHT; acne and hair loss cannot occur. Androgenic side effects associated with virilization in women are also impossible. As there is no direct androgenic activity related to DHT, prostate issues should also be non-existent.

Cardiovascular side effects

The side effects of Ostarine should present minimal cardiovascular risk. Both HDL and LDL levels may be reduced, but all data shows minimal to insignificant reductions.

Testosterone Suppression

It’s often said SARM’s will not suppress natural testosterone production, and it’s true they will not compared to anabolic steroids. However, some suppression is possible, but complete suppression is not. A testosterone-boosting supplement may be warranted while using MK 2866. Post Cycle Therapy (PCT) data is somewhat inconclusive as to if this is needed. Some men seem to experience greater levels of testosterone suppression than others.

Hepatotoxicity

Although orally administered, the side effects of Ostarine do not include liver toxicity. MK 2866 does not belong to the C17-alpha alkylated (C17-aa) class of drugs like many oral anabolic steroids. It does not mirror the MI metabolite associated with the SARM S4 that gives that particular SARM some hepatic activity.

Post Cycle Therapy (PCT) after Ostarine

Theoretically SARMs cannot be aromatized, conferring all their effects to AR binding and not to metabolic conversion to active androgens/estrogens. However there is a lot of conflicting information floating around on various bodybuilding forums, mainly due to sellers who push SARMs and make wild claims while on the other side people with no first hand experience making uneducated guesses. This “information” then gets perpetuated and repeated.

Most people seem to agree that natural testosterone suppression caused by Ostarine is relatively light if there is any. To counter this, people use mild PCT (for example 10-20mg Nolvadex once per day during 4 weeks after the Ostarine cycle).

Ostarine compared to Steroids and Prohormones

  • There is no need for pre cycle supports
  • There is no need for on cycle supports such as milk thistle for the liver, policosanol or RYR for cholesterol etc.
  • Some suppression may be present at doses of 25mg+ run for longer than 4 weeks, however a stringent PCT of prescription SERMs like Nolva or Clomid is not necessary.
  • High oral biovailabilty without significant damage to your liver as with oral steroids/prohormones.
  • Great sense of well being while on, (without the aggression which can often detrimentally impact users daily lifes).
  • No need for a long time period off between cycles; the recommended time of period for normal cycles would be Time on +PCT, so for a typical 6 week cycle and 4 week PCT, a user would have to wait another 10 weeks after PCT to start another cycle.
  • Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk category – hence there is little impact on cholesterol values.

Ostarine compared to other SARMs

  • The metabolite M1 wich seems to cause toxicity in S4 (temporary occular disturbances) is not present in Ostarine.
  • Also unlike S4, Ostarine does not have androgenic properties in non muscle tissue.

Clinical Trials

Ostarine demonstrated good results in Phase I and II clinical trials, increasing total lean muslce mass, enhancing strength and decreasing total tissue percent fat. Ostarine performs as a potent anabolic agent with minimal side effects on other organs (hair follicles, prostate) which are usually affected by the use of steroids.

Until now, GTx has evaluated MK-2866 in 8 clinical trials, involving 600 subjects, including three efficacy studies. A 4-month Phase II.b clinical trial enrolled 159 patients with the study confirming its primary objective of an absolute total lean body mass increase and the secondary objective increase in muscle function.

Thanks isarms.com, evolutionary.org, moreplatesmoredates.com, steroid.com

UK prohormones and SARMs
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