MK 677 (Ibutamoren, Nutrobal) is known as a SARM which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. Altough MK-677 is mostly referred as a SARM technically it is not a Selective Androgen Receptor Modulator. In fact Ibutamoren is a GH secretagogue that signals the pituitary gland in your body to secrete more growth hormone. MK-677 is mimicking ghrelin that is referred to as the hunger hormone. It is produced by ghrelin cells in the GI tract which functions as a neuropeptide in the central nervous system. Ghrelin also plays a significant role in regulating the distribution and rate of energy use.
It is important to understand these concepts to understand all the capabilities MK-677 possesses. Ibutamoren has shown to not only increase the release of but also produce sustained increases in plasma levels of many types of hormones. At the top of this list are growth hormone and IGF-1, all the while with no affect on cortisol levels. At this time, it is under development as a treatment for reduced levels of both hormones. Examples of this treatment would include growth hormone deficient individuals. Human studies have shown that MK-677 will increase both bone mineral density and muscle mass. Ibutamoren also alters metabolism of body fat and so may have application in the treatment of obesity.
How MK 677 works
Ibutamoren is a GH secretagogue taken orally (no injections needed). A GH secretagogue is simply a substance that signals the pituitary gland in your body to secrete more growth hormone. After orally taking a dose of MK-677, the compound will vastly increase the release of Growth Hormone (GH) and Insulin-Life Growth Factor 1 (IGF-1) for the next 24 hours via strong GH pulsations exerted in the pituitary gland. These strong GH pulses MK-677 causes your body to create are much like the growth hormone releasing peptides that you may be more familiar with like GHRP-6, GHRP-2, Ipamorelin and Hexarelin.
The most amazing thing, Ibutamoren causes over a dozen of these extremely strong GH pulsations over the next 24 hours from a single dose, and they don’t need injections at all like ALL other growth hormone releasing peptides require.
MK-677 also greatly improves your ability to burn fat, thus making it a very viable option for the treatment of obesity in the future.
Ibutamoren will not negatively affect your testosterone levels in any capacity at all, so there is literally NO chance of any hormonal suppression. Consequently, you don’t need to take an aromatase inhibitor or complete a PCT phase after taking MK-677.
Benefits of Ibutamoren
Elevated growth hormone has literally endless list of benefits to the human body, why do you think everyone tries to get their hands on HGH? That’s why Mk-677 is so effective, it increases Growth Hormone and IGF-1 levels.
As the studies show, Ibutamoren can be used for a number of reasons from growing muscle mass, to getting shredded. It does not compete with the levels of growth hormone one can get from exogenously administered HGH, so you can use it with hgh cycles. In fact, by using nutrobal, you can easily get amazing increases of your own natural growth hormone pulses without having to deal with annoying and painful daily HGH injections. It’s like using HGH without having to inject daily.
Detailed MK-677 benefits
- Ibutamoren doesn’t require any injections as it has a high level of oral bioavailability
- Only one dose is needed per day to reap all the benefits MK-677 has to offer while synthetic HGH injections and GH peptide injections need to be pinned several times per day which can be a nuisance, not to mention extremely inconvenient if you are traveling (good luck storing your HGH and peptides in a fridge and getting all your injections in each day while traveling).
- MK-677 causes 12 very strong GH pulsations from your pituitary gland after ingestion (you would need to inject GHRP-6 12+ times per day to achieve this same benefit from peptides)
- It is stored at room temperature making it convenient for travel (HGH and GH peptides need to be stored in a fridge like I mentioned previously)
- IGF-1 levels continue to increase with each consecutive day of use to extremely high levels (each consecutive dose continuously increases how much muscle your body is capable of packing on)
- Body fat melts off so much easier
- Weight gain is rapid and very noticeable (in a good way). It isn’t uncommon for someone to gain up to 10 pounds within their first week of using Ibutamoren
- Sleep quality is deeper and dramatically improved from the increased GH output
- Endurance is greatly enhanced
- Improvement of your complexion
- Dramatic increases in nitrogen retention result in crazy muscular fullness
- Big increases of strength
- Immune system operates at a heightened level
Usual dosage of Ibutamoren is 5mg-25 mg per day. The half life of MK-677 is 24 hours and is best tolerated when taken in the morning on an empty stomach. It provides a large improvement in sleep benefit however it can interfere with sleep if taken too late at night as opposed to the morning, making morning dosing optimal. The high end dosing protocol for Ibutamoren is 50 mg per day but it has shown to consistently be the best tolerated and show the most positive effect at 25 mg per day. It is fine to ease into it and assess your body response. It has shown to be best utilized in the safest and most effective manner at 25 mg per day. This dosing has shown to be the sweet spot. Many studies have shown MK-677 to be used in one and two year intervals with no adverse reactions and no desensitizing issues. This makes it very desirable for use as well.
Side effects of Ibutamoren
- Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677.
- Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
- Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you’re prone to prolactin sides? If you get gynecomastia from taking trenbolone, you’re prone to prolactin sides.
Stack for endurance
Stack it with 20 mg a day of cardarine for a lethal endurance stack, and blow away your competition on your next bicycle/road race. MK-677 would work beautifully for this purpose.
Stack for fat loss
Stack it with andarine and cardarine to get a lethal fat burning triple stack.
Stack for mass gain
Stack it with LGD and anabolic steroids, we will be able to gain mass without the fear of spiking your body fat measurement.
Stack for overall health
MK-677 can give an improved mood, sleep, cholesterol levels, injury healing and immune system boosting.
Thanks isarms.com, evolutionary.org, moreplatesmoredates.com