Andarine (S4) – Perfect SARM for Stacking

Anadarine (S4) is a SARM (Selective androgen receptor modulator), that binds firmly to the androgen receptors. Its chemical name is S-3-(4-acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylpheanyl) propionamide. S4 Andarine was developed in the treatment of muscle wasting diseases, osteoporosis and  enlargement of the prostate. Unlike an anabolic androgenic steroid, S4 Andarine focuses only on the bone and muscle sites unlike other androgenic compounds that may affect secondary sex organs. By binding to the androgen receptors, S4 Andarine alters the gene expression, thereby increasing anabolism via increases in protein synthesis. Although a highly effective compound, in comparison to its binding affinity it is approximately one third that of testosterone.

Benefits of Andarine

  • Powerful pro-anabolic compound
  • Can be used by males and females
  • Increases lean muscle mass
  • Increases strength and endurance
  • Promotes fat loss
  • Promotes recovery
  • Increases libido

S4 Andarine uses

 S4 Andarine attaches to the AR and sticks to it; each time the AR interacts with testosterone, S4 forces it to produce genes that exclusively benefit muscle and bone growth. In other words, Andarine is a form of SARM that attaches to the androgen receptor (AR) the same with regular androgens, the only variation is that S4 generates selective anabolic activity.

Due to the fact that  S4 Andarine binds to androgen receptors, it can increase strength and build lean muscle mass without creating water weight, drying out the joints, stressing the liver, or causing severe suppression. What’s more, there is strong evidence that S4 also helps prevent osteoporosis, meaning that it will strengthen bones and soft tissues within the body. Likewise, andarine is great at preventing muscle wasting for those who choose to use it as a bridge between steroid cycles in order to keep muscle mass gains.

Dosing of S4 Andarine

Andarine S4 is taken orally, normally in liquid form although capsules are also available. The common dosing range of S4 is 50-75mg per day taken evenly throughout the day. Andarine carries a half-life of approximately four hours. Results may be seen in as little as four weeks, but most will find six weeks to be the minimum time frame for decent results to be seen with 8-10 weeks being fairly common. Andarine can be stacked with other SARM’s, with anabolic steroids, peptides or nearly any performance based medication. Some will choose to take it in between steroid cycles as they are attempting to let testosterone levels recover; however, note they will not recover when this SARM is in play.

S4 Andarine for cutting

The typical dose for cutting is 50 mg for a cycle of 8 to 10 weeks. The cycle should include using the product daily for 5 days and then taking 2 days off for the duration. Tasking the dose every day for the duration of the cycle can result in changes to vision.

Stacking S4 Andarine

Andarine can be used by itself, but it works even better when stacked because different drugs and compounds will work in synergy. There are a few ways to stack andarine, which I will illustrate below. All milligram (mg) examples are daily dosages, and you can run Andarine for up to 12 weeks at a time.

Endurance stack

You can stack andarine at a low dose with Cardarine (GW 501516) at 20mg per day for an increase in endurance.

Cutting stack

The best shredder stack would be the combination of 20mg of Cardarine (GW-501516) with 50-75mg of S4 Andarine. This combination is well known as a potent ‘cutting’ stack.

Anabolic steroid stack

Stacking S4 Andarine as part of an anabolic steroid cycle is a good way to help increase strength and lean muscle mass without giving additional side effects to your cycle.

Recomp stack

If you want to recomp, andarine stacks beautifully with Cardarine (GW-501516) and Ostarine (MK 2866).

Side effect of S4 Andarine

Vision disturbances

Andarine is known for one side effect – its affinity to bind to the androgen receptors in the eyes, which is not permanent or harmful. When this happens, the user may have problems adjusting their vision from darkness to light, or they will notice a yellow tint. If this becomes a problem, you can lower the dose down or take a couple days off from taking it. Therefore, there is nothing to worry about because once the compound is stopped, your vision will return to normal within a few days to a week.

Testosterone Suppression

The side effects of Andarine (S4) will include the suppression of natural testosterone production. The rate of suppression will not be as significant as with an anabolic steroid, but may be more significant than with other SARMs. How much suppression exists will be dependent on dose and genetic factors. Post Cycle Therapy (PCT) may or may not be needed. If used with an anabolic steroid it will certainly be needed.

Estrogenic side effects

Estrogenic side effects of Andarine (S4) should not occur as the SARM does not aromatize (conversion of testosterone to estrogen). Gynecomastia (male breast enlargement), water retention or high blood pressure due to severe water retention should not occur with this SARM. However, some data has shown the SARM to promote slight increases in serum estradiol levels, although not significant enough to create estrogenic side effects associated with some anabolic steroids.

Androgenic sides

There should be no androgenic side effects of Andarine (S4). Hair loss, acne and virilization symptoms in women (masculine trait promotion) are impossible with this medication. Although S4 does bind to the androgen receptor, it only activates in the bone and muscle target areas and not others associated with androgenic issues.


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